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MAY 2018  2017


We are very proud to be involved with this cutting edge technology from LIG-NANOWISE.

The following extract is taken from their brochure - download the brochure for more information & examples of their work.

What is SMAL?

Super-resolution Microsphere Amplified Lens


NANOPSIS is the imaging brand of LIG Nanowise - a

Manchester based start-up that specialises in the application  of microsphere technology to solve the problems facing industry and R&D, based in the Manchester Science Park.


We specialise in nanotechnology - we are always using microscopes to view structures sub 200 nm in size. Sending samples to be imaged was slow, expensive, and took more effort than it was worth. We became tired of using SEM microscopes that were too large, loud, and too expensive to run in our own lab, and STED and STORM didn’t suit our requirements so we had a bright idea.  

STED and STORM have taken confocal microscopy into super-resolution - why not expand the range of wide-field optical microscopy? The result is the SMAL. It works in reflection mode in the wide-field, and allows you to add super-resolution imaging to your routine work. We aren’t proposing to replace SEMs, STED or STORM, what SMAL offers is an easy, cost effective way, to examine samples beyond the range of standard optical microscopy. If you have ever used a white-light microscope you will be right at home using the NANOPSIS M.


The basic principle of SMAL was first demonstrated in 2013by Professor Lin Li, the chairman of LIG Nanowise. His work on SMON (Submerged Microsphere Optical Nanoscope) was published in the journal Light: Science and Applications in 2013. It was a nice demonstration of the power of microspheres, but SMON was never going to be repeatable, easy to use, or cost effective.